Magnesium Deficiency in Chemotherapy
Magnesium Deficiency in Chemotherapy
Magnesium is a crucial mineral that supports various cellular functions, participating in over 300 enzymatic reactions related to muscle contraction, blood pressure regulation, and protein synthesis. Its importance in muscle physiology and cardiovascular health has become increasingly clear over the last decade.
In modern chemotherapy, new agents are regularly introduced to target cancer cells and inhibit their growth. These include biologics that block specific proteins cancer cells rely on and immunotherapy that stimulates the immune system to attack abnormal cells. Often, treatments combine multiple approaches. Although tolerance to these newer drugs has generally improved, they can cause significant electrolyte imbalances, leading to various side effects.
Common Side Effects of Chemotherapy
Chemotherapy side effects are particularly pronounced with anti-proliferative agents that hinder cell replication. Common issues include hair loss, fatigue, anemia, low white blood cell counts, rashes, and gastrointestinal disturbances like diarrhea, nausea, vomiting, and loss of appetite, which can lead to dehydration.
Different chemotherapeutic agents can trigger distinct reactions, but muscle soreness, weakness, and fatigue are often linked to imbalances in key electrolytes: sodium, magnesium, and potassium. These imbalances frequently result from losses due to diarrhea and dehydration, making electrolyte replacement essential for reducing side effects.
Magnesium Deficiency from Chemotherapy
Chemotherapy can significantly deplete magnesium levels through gastrointestinal loss and increased urinary excretion. Patients already deficient in magnesium—often without knowing it—are particularly at risk. Diagnosing magnesium deficiency typically requires blood tests; however, since magnesium shifts between blood, cells, and tissues, a blood sample may not reflect true deficiency levels.
Once chemotherapy begins, vulnerable patients may experience a rapid loss of electrolytes, leading to symptoms such as fatigue, weakness, muscle cramps, sleep disturbances, mood changes, and irritability.
Benefits of a Magnesium-Rich Diet
Incorporating magnesium-rich foods into the diet can help mitigate the impact of chemotherapy and support overall health.
To learn how HuMOLYTE can aid in hydrating patients during chemotherapy and alleviating chemotherapy side effects, visit here.
About Dr. Sourabh Kharait
Dr. Sourabh Kharait (MD / PhD) is Clinical Nephrologist and Medical Director of Clinical Trials at Summit Nephrology Medical Group, and the Founder and CEO of IGH Naturals, a platform company that designs Functional Foods and Nutritional products for athletes and patients with chronic diseases.Whatever it is, the way you tell your story online can make all the difference.
